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“Antioxidants (AOs) are molecules, which when present at low concentrations compared to those of an oxidizable substrate, will significantly delay or inhibit oxidation of that substance.”[3,4] They cease destructive chain reactions started by ROS.[1] Living organism cells have developed numerous AO defense systems to contain ROS mediated damage, viz enzymatic AOs such as peroxidases,[5] thiol-containing peptides such as glutathione and thioredoxine, and sophisticated transcriptional programs such as ones controlled by Forkhead box O.[6] Melatonin, which is N-acetyl-5-methoxy-tryptamine, mainly produced by pineal gland, has also been shown to encompass powerful free-radical scavenger activity.[7,8] Currently, AOs have been categorized according to their location of action (intracellular, extracellular or membrane associated)
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Targets a Senescent-Cell Survival Interaction : Competes with FOXO4 for p53 binding, disrupting a pathway linked to senescent-cell persistence in preclinical models
